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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells
🧠 Breakthrough in Alzheimer's Research: Cannabinoids have been found to remove plaque-forming proteins from brain cells, offering a potential therapeutic approach to treating Alzheimer's disease by directly targeting the proteins that contribute to the disease's progression, and providing new hope for patients and families affected by this devastating condition.
1:05 am, March 16, 2026
guid
https://news.ycombinator.com/item?id=47393619
source_url
https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/
author_name
anjel
id: 856
uid: fJe0d
insdate: 2026-03-16 01:05:06
title: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells
additional: 🧠 Breakthrough in Alzheimer's Research: Cannabinoids have been found to remove plaque-forming proteins from brain cells, offering a potential therapeutic approach to treating Alzheimer's disease by directly targeting the proteins that contribute to the disease's progression, and providing new hope for patients and families affected by this devastating condition.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47393619
source_url: https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/
updated:
image:
author_name: anjel
author_link:
uid: fJe0d
insdate: 2026-03-16 01:05:06
title: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells
additional: 🧠 Breakthrough in Alzheimer's Research: Cannabinoids have been found to remove plaque-forming proteins from brain cells, offering a potential therapeutic approach to treating Alzheimer's disease by directly targeting the proteins that contribute to the disease's progression, and providing new hope for patients and families affected by this devastating condition.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47393619
source_url: https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/
updated:
image:
author_name: anjel
author_link:
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- Little Free Library Books
- Living human brain cells play DOOM on a CL1 [video]
- LoGeR – 3D reconstruction from extremely long videos (DeepMind, UC Berkeley)
- Looks like it is happening
- Lost Doctor Who Episodes Found
- Love of corporate bullshit is correlated with bad judgment
- MAUI Is Coming to Linux
- MCP is dead. Long live the CLI
- Mac external displays for designers and developers, part 2 (2022)
- MacBook M5 Pro and Qwen3.5 = Local AI Security System
- Mac mini will be made at a new facility in Houston
- Making Firefox's right-click not suck with about:config
- Making MCP cheaper via CLI
- Making Wolfram tech available as a foundation tool for LLM systems
- Manjaro website off-line again due to lapsed certificate
- Many SWE-bench-Passing PRs would not be merged
- Measuring progress toward AGI: A cognitive framework
- Medical journal says the case reports it has published for 25 years are fiction
- Megadev: A Development Kit for the Sega Mega Drive and Mega CD Hardware
- Men in their 50s may be aging faster due to toxic 'forever chemicals'
- Mercury 2: Fast reasoning LLM powered by diffusion
- Mercury 2: The fastest reasoning LLM, powered by diffusion
- Mesh over Bluetooth LE, TCP, or Reticulum
- Meta Horizon Worlds on Meta Quest is being discontinued
- Meta and TikTok let harmful content rise to drove engagement, say whistleblowers
- Meta’s AI smart glasses and data privacy concerns
- Meta’s renewed commitment to jemalloc
- Meticulous (YC S21) is hiring to redefine software dev
- Michael Pollan punctures the AI bubble
- Microgpt
- Microslop Manifesto
- Microsoft BitNet: 100B Param 1-Bit model for local CPUs
- Microsoft Creative Writer (1993)
- Microsoft bans the word "Microslop" on its Discord, then locks the server
- Microsoft's 'unhackable' Xbox One has been hacked by 'Bliss'
- Migrating the American Express Payment Network, Twice
- Militaries are scrambling to create their own Starlink
- MinIO Is Dead, Long Live MinIO
- Mistral AI Releases Forge
- MitID, Denmarks sole digital ID, has been down for over an hour and counting
- Monkey Island for Commodore 64 Ground Up
- MonoGame: A .NET framework for making cross-platform games
- More common mistakes to avoid when creating system architecture diagrams
- Most of the US economy is in a recession
- Motorola announces a partnership with GrapheneOS Foundation
- Mouser: An open source alternative to Logi-Plus mouse software
- Mozilla to launch free built-in VPN in upcoming Firefox 149
- Mullvad VPN: Banned TV Ad in the Streets of London [video]
- Multifactor (YC F25) Is Hiring an Engineering Lead
- My Homelab Setup
- NASA announces major overhaul of Artemis program amid safety concerns, delays
- NASA announces overhaul of Artemis program amid safety concerns, delays
- NMAP in the Movies
- NRC Issues First Commercial Reactor Construction Approval in 10 Years [pdf]
- NRC issues first commercial reactor construction approval in 10 years [pdf]
- Nango (YC W23, API Access for Agents and Apps) Is Hiring
- Nano Banana 2: Google's latest AI image generation model
- NanoGPT Slowrun: Language Modeling with Limited Data, Infinite Compute
- Nasdaq's Shame
- Ndea (YC W26) is hiring a symbolic RL search guidance lead
- Nearby Glasses
- Netflix Backs Out of Warner Bros. Bidding, Paramount Set to Win
- Networking with agents: Put them in the right conversations with Tailscale
- Never Bet Against x86
- Never Buy A .online Domain
- New AirSnitch attack breaks Wi-Fi encryption in homes, offices, and enterprises
- New California law requires age verification for all OS accounts
- New York could prohibit chatbot medical, legal, engineering advice
- New accounts on HN 10x more likely to use em-dashes
- New iron nanomaterial wipes out cancer cells without harming healthy tissue
- Nightingale – open-source karaoke app that works with any song on your computer
- Nihilistic Violent Extremism
- No evidence cannabis helps anxiety, depression, or PTSD
- No right to relicense this project
- No, it doesn't cost Anthropic $5k per Claude Code user
- Nobody Gets Promoted for Simplicity
- Node.js needs a virtual file system
- Noq: n0's new QUIC implementation in Rust
- North Korean's 100k fake IT workers net $500M a year for Kim
- Notes on Baking at the South Pole
- Notes on Lagrange Interpolating Polynomials
- Notes on Writing WASM
- Number Research Inc
- Number of UK workers on zero-hours contracts hits record high ahead of crackdown
- Nvidia Launches Vera CPU, Purpose-Built for Agentic AI
- Nvidia NemoClaw
- Nvidia PersonaPlex 7B on Apple Silicon: Full-Duplex Speech-to-Speech in Swift
- Nvidia backs AI data center startup Nscale as it hits $14.6B valuation
- Obsidian Sync now has a headless client
- Office.eu launches as Europe's sovereign office platform
- Oil Is Near a Price That Hurts the Economy
- Oil nears $110 a barrel after gas field strike
- Online astroturfing: A problem beyond disinformation
- Open Letter to Google on Mandatory Developer Registration for App Distribution
- Open Source Endowment – new funding source for open source maintainers
- Open source calculator firmware DB48X forbids CA/CO use due to age verification
- OpenAI Fires an Employee for Prediction Market Insider Trading
- OpenAI agrees with Dept. of War to deploy models in their classified network
- OpenAI fires an employee for prediction market insider trading
- OpenAI is walking away from expanding its Stargate data center with Oracle
- OpenAI reaches deal to deploy AI models on U.S. DoW classified network
- OpenAI resets spending expectations, from $1.4T to $600B
- OpenAI – How to delete your account
- OpenAI's $110B funding round (investments from Amazon, Nvidia, SoftBank)
- OpenAI, the US government and Persona built an identity surveillance machine
- OpenBSD on SGI: A Rollercoaster Story
- OpenClaw Surpasses React to Become the Most-Starred Software Project on GitHub
- OpenClaw is a security nightmare dressed up as a daydream
- OpenCode – Open source AI coding agent
- OpenCode – The open source AI coding agent
- OpenSUSE Kalpa
- OpenTitan Shipping in Production
- Operational issue – Multiple services (UAE)
- Optimizing Content for Agents
- Oracle is building yesterday's data centers with tomorrow's debt
- Oregon school cell phone ban: 'Engaged students, joyful teachers'
- Origin of the rule that swap size should be 2x of the physical memory
- Osaka: Kansai Airport proud to have never lost single piece of luggage (2024)
- OsmAnd's Faster Offline Navigation
- OsmAnd's Faster Offline Navigation (2025)
- Otters as Bioindicators of Estuarine Health
- Our Agreement with the Department of War
- Our Computer Using agent just solved CAPTCHA up to Level 6
- Our Experience with I-Ready
- PA Bench: Evaluating Frontier Models on Multi-Tab Pa Tasks
- PA bench: Evaluating web agents on real world personal assistant workflows
- PC Gamer recommends RSS readers in a 37mb article that just keeps downloading
- PC processors entered the Gigahertz era today in the year 2000 with AMD's Athlon
- Packaging a Gleam app into a single executable
- Palantir extends reach into British state as gets access to sensitive FCA data
- Palantir's AI Is Playing a Major Role in Tracking Gaza Aid Deliveries
- Palm OS User Interface Guidelines (2003) [pdf]
- Palm OS User Interface Guidelines [pdf, 2003]
- Parakeet.cpp – Parakeet ASR inference in pure C++ with Metal GPU acceleration
- Parallel coding agents with tmux and Markdown specs
- Parallels confirms MacBook Neo can run Windows in a virtual machine
- Pass-Through of Tariffs: Evidence from European Wine Imports
- Passengers who refuse to use headphones can now be kicked off United flights
- Paul Brainerd, Founder of Aldus PageMaker, has died
- Pentagon chief blocks officers from Ivy League schools and top universities
- Pentagon expands oversight of Stars and Stripes, limits content
- Pentagon threatens to make Anthropic a pariah
- Personal Computer by Perplexity
- Philosoph Jürgen Habermas Gestorben
- Physicists Trace Sun's Magnetic Engine, 200k Kilometers Below Surface
- Physicists developing a quantum computer that’s entirely open source
- Physics Girl: Super-Kamiokande – Imaging the sun by detecting neutrinos [video]
- Pi – A minimal terminal coding harness
- Pi – a minimal terminal coding harness
- Plasma Bigscreen – 10-foot interface for KDE plasma
- Plastic is made from milk and it vanishes in 13 weeks
- Please do not use auto-scrolling content on the web and in applications
- Please, please, please stop using passkeys for encrypting user data
- Poll: Code with AI or Not?
- Polymarket gamblers threaten to kill me over Iran missile story
- Poor Man's Polaroid
- Porn depicting sex between step-relatives set to be banned in the UK
- Possible US Government iPhone-Hacking Toolkit in foreign spy and criminal hands
- PostmarketOS in 2026-02: generic kernels, bans use of generative AI
- Preliminary data from a longitudinal AI impact study
- President Trump bans Anthropic from use in government systems
- Privacy-preserving age and identity verification via anonymous credentials
- Process-Based Concurrency: Why Beam and OTP Keep Being Right
- Professional video editing, right in the browser with WebGPU and WASM
- Profiling Hacker News users based on their comments
- Prompt-caching – auto-injects Anthropic cache breakpoints (90% token savings)
- Proton Mail Helped FBI Unmask Anonymous 'Stop Cop City' Protester
- Psychology: Who dont maintain many close friends, learned independence too early
- Push events into a running session with channels
- Put the zip code first
- Python 3.15's JIT is now back on track
- QGIS 4.0
- Qt45: A small polymerase ribozyme that can synthesize itself
- Quillx is an open standard for disclosing AI involvement in software projects
- Qwen3.5 122B and 35B models offer Sonnet 4.5 performance on local computers
- RAM kits are now sold with one fake RAM stick alongside a real one
- RAM now represents 35 percent of bill of materials for HP PCs
- RFC 9849. TLS Encrypted Client Hello
- RISC-V Is Sloooow
- RX – a new random-access JSON alternative
- Rack-Mount Hydroponics
- Rack-mount hydroponics
- Racket v9.1
- Red Dwarf creator Rob Grant has died
- Red Hat takes on Docker Desktop with its enterprise Podman Desktop build
- Reddit User Uncovers Who Is Behind Meta's $2B Lobbying for Age Verification Tech
- Redox OS has adopted a Certificate of Origin policy and a strict no-LLM policy
- Reflex (YC W23) Is Hiring Software Engineers – Python
- Relax NG is a schema language for XML (2014)
- Reliable Software in the LLM Era
- Relicensing with AI-Assisted Rewrite
- Remotely unlocking an encrypted hard disk
- Rendezvous with Rama
- Revealed: Face of 75,000-year-old female Neanderthal from cave
- Reverse-engineering Viktor and making it Open Source
- Reversing memory loss via gut-brain communication
- Right-sizes LLM models to your system's RAM, CPU, and GPU
- Rob Grant, creator of Red Dwarf, has died
- Rob Pike's 5 Rules of Programming
- Roboflow (YC S20) Is Hiring a Security Engineer for AI Infra
- Robotocore · a Digital Twin of AWS
- Runners who churn butter on their runs
- Running a One Trillion-Parameter LLM Locally on AMD Ryzen AI Max+ Cluster
- Rust Is Just a Tool
- Rust is just a tool
- Ryugu asteroid samples contain all DNA and RNA building blocks
- SBCL Fibers – Lightweight Cooperative Threads
- SBCL: A Sanely-Bootstrappable Common Lisp (2008) [pdf]
- SIM (YC X25) Is Hiring the Best Engineers in San Francisco
- SSH has no Host header
- SWE-CI: Evaluating Agent Capabilities in Maintaining Codebases via CI
- Samsung Galaxy update removes Android recovery menu tools, including sideloading
- Sandboxes won't save you from OpenClaw
- Sarvam 105B, the first competitive Indian open source LLM
- Sashiko: An agentic Linux kernel code review system
- Scaling Karpathy's Autoresearch: What Happens When the Agent Gets a GPU Cluster
- Scientists discover a surprising way to quiet the anxious mind (2025)
- Scrt: A CLI secret manager for developers, sysadmins and DevOps
- Sea level much higher than assumed in most coastal hazard assessments
- Searching for the Agentic IDE
- Seed of Might Color Correction Process (2023) [pdf]
- Self-improving software won't produce Skynet
- Sem – Semantic version control. Entity-level diffs on top of Git
- Senior European journalist suspended over AI-generated quotes
- Separating the Wayland compositor and window manager
- Setting up OpenClaw on a cloud VM
- Shall I implement it? No
- Show HN: A context-aware permission guard for Claude Code
- Show HN: A real-time strategy game that AI agents can play
- Show HN: ANSI-Saver – A macOS Screensaver
- Show HN: Agent Swarm – Multi-agent self-learning teams (OSS)
- Show HN: Algorithms and Data Structures in TypeScript – Free Book (~400 Pages)
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- Show HN: Atomic – self-hosted, semantically-connected personal knowledge base
- Show HN: Audio Toolkit for Agents
- Show HN: Aurion OS – A 32-bit GUI operating system written from scratch in C
- Show HN: Autoresearch@home
- Show HN: Badge that shows how well your codebase fits in an LLM's context window
- Show HN: Baltic shadow fleet tracker – live AIS, cable proximity alerts
- Show HN: Better Hub – A better GitHub experience
- Show HN: Claude-File-Recovery, recover files from your ~/.claude sessions
- Show HN: Claude-replay – A video-like player for Claude Code sessions
- Show HN: Clocksimulator.com – A minimalist, distraction-free analog clock
- Show HN: Context Gateway – Compress agent context before it hits the LLM
- Show HN: Context Mode – 315 KB of MCP output becomes 5.4 KB in Claude Code
- Show HN: Curiosity – DIY 6" Newtonian Reflector Telescope
- Show HN: Decided to play god this morning, so I built an agent civilisation
- Show HN: Deff – side-by-side Git diff review in your terminal
- Show HN: Django Control Room – All Your Tools Inside the Django Admin
- Show HN: Duplicate 3 layers in a 24B LLM, logical deduction .22→.76. No training
- Show HN: Emdash – Open-source agentic development environment
- Show HN: Eyot, A programming language where the GPU is just another thread
- Show HN: Free OpenAI API Access with ChatGPT Account
- Show HN: GDSL – 800 line kernel: Lisp subset in 500, C subset in 1300
- Show HN: Gapless.js – gapless web audio playback
- Show HN: Giggles – A batteries-included React framework for TUIs
- Show HN: Global Maritime Chokepoints
- Show HN: Govbase – Follow a bill from source text to news bias to social posts
- Show HN: GrobPaint: Somewhere Between MS Paint and Paint.net
- Show HN: Han – A Korean programming language written in Rust
- Show HN: Horizon – GPU-accelerated infinite-canvas terminal in Rust
- Show HN: I Was Here – Draw on street view, others can find your drawings
- Show HN: I built 48 lightweight SVG backgrounds you can copy/paste
- Show HN: I built a real-time OSINT dashboard pulling 15 live global feeds
- Show HN: I built a site where you hire yourself instead of applying for jobs
- Show HN: I built a sub-500ms latency voice agent from scratch
- Show HN: I built a tool that watches webpages and exposes changes as RSS
- Show HN: I ported Tree-sitter to Go
- Show HN: I'm 15. I mass published 134K lines to hold AI agents accountable
- Show HN: Joonote – A note-taking app on your lock screen and notification panel
- Show HN: Klaus – OpenClaw on a VM, batteries included
- Show HN: Kula – Lightweight, self-contained Linux server monitoring tool
- Show HN: Learn Arabic with spaced repetition and comprehensible input
- Show HN: Logira – eBPF runtime auditing for AI agent runs
- Show HN: Mcp2cli – One CLI for every API, 96-99% fewer tokens than native MCP
- Show HN: Moonshine Open-Weights STT models – higher accuracy than WhisperLargev3
- Show HN: Now I Get It – Translate scientific papers into interactive webpages
- Show HN: Omni – Open-source workplace search and chat, built on Postgres
- Show HN: OneCLI – Vault for AI Agents in Rust
- Show HN: Online OCR Free – Batch OCR UI for Tesseract, Gemini and OpenRouter
- Show HN: Open-source playground to red-team AI agents with exploits published
- Show HN: OpenClaw-class agents on ESP32 (and the IDE that makes it possible)
- Show HN: OpenSwarm – Multi‑Agent Claude CLI Orchestrator for Linear/GitHub
- Show HN: Out Plane – A PaaS I built solo from Istanbul in 3 months
- Show HN: PHP 8 disable_functions bypass PoC
- Show HN: PageAgent, A GUI agent that lives inside your web app
- Show HN: Pianoterm – Run shell commands from your Piano. A Linux CLI tool
- Show HN: Playing LongTurn FreeCiv with Friends
- Show HN: Poppy – a simple app to stay intentional with relationships
- Show HN: Reclaim Flowers – A 2D physics-based "Digital Altar" protocol
- Show HN: Recursively apply patterns for pathfinding
- Show HN: Red Grid Link – peer-to-peer team tracking over Bluetooth, no servers
- Show HN: RetroTick – Run classic Windows EXEs in the browser
- Show HN: Rev-dep – 20x faster knip.dev alternative build in Go
- Show HN: Revise – An AI Editor for Documents
- Show HN: Rust-powered document chunker for RAG – 40x faster, O(1) memory
- Show HN: SNKV – SQLite's B-tree as a key-value store (C/C++ and Python bindings)
- Show HN: SQLite for Rivet Actors – one database per agent, tenant, or document
- Show HN: Sgai – Goal-driven multi-agent software dev (GOAL.md → working code)
- Show HN: SignalCend – API that resolves conflicting IoT device state in 47ms
- Show HN: Signet – Autonomous wildfire tracking from satellite and weather data
- Show HN: Simple plugin to get Claude Code to listen to you
- Show HN: Skir – like Protocol Buffer but better
- Show HN: Sonar – A tiny CLI to see and kill whatever's running on localhost
- Show HN: SplatHash – A lightweight alternative to BlurHash and ThumbHash
- Show HN: Steerling-8B, a language model that can explain any token it generates
- Show HN: Swarm – Program a colony of 200 ants using a custom assembly language
- Show HN: Terminal Phone – E2EE Walkie Talkie from the Command Line
- Show HN: Terminal-Style Portfolio on the Internet
- Show HN: The Mog Programming Language
- Show HN: The Roman Industrial Revolution that could have been (Vol 2)
- Show HN: Timber – Ollama for classical ML models, 336x faster than Python
- Show HN: Tmux-IDE, OSS agent-first terminal IDE
- Show HN: Tomoshibi – A writing app where your words fade by firelight
- Show HN: Trackm, a personal finance web app
- Show HN: Understudy – Teach a desktop agent by demonstrating a task once
- Show HN: VS Code Agent Kanban: Task Management for the AI-Assisted Developer
- Show HN: Vanilla JavaScript refinery simulator built to explain job to my kids
- Show HN: Vertex.js – A 1kloc SPA Framework
- Show HN: We built a terminal-only Bluesky / AT Proto client written in Fortran
- Show HN: Web Audio Studio – A Visual Debugger for Web Audio API Graphs
- Show HN: Will my flight have Starlink?
- Show HN: X86CSS – An x86 CPU emulator written in CSS
- Show HN: Xmloxide – an agent made rust replacement for libxml2
- Show HN: ZSE – Open-source LLM inference engine with 3.9s cold starts
- Show HN: enveil – hide your .env secrets from prAIng eyes
- Show HN: fftool – A Terminal UI for FFmpeg – Shows Command Before It Runs
- Show HN: s@: decentralized social networking over static sites
- Show HN: uBlock filter list to blur all Instagram Reels
- SigNoz (YC W21, open source Datadog) Is Hiring across roles
- Smalltalk's Browser: Unbeatable, yet Not Enough
- Smartphone Mkt to Decline 13% in '26, Largest Drop Ever Due to Memory Shortage
- Smartphone market forecast to decline this year due to memory shortage
- So you want to write an “app” (2025)
- Software 3.1? – AI Functions
- Some Things Just Take Time
- Someone Needs to Go to Jail
- Something is afoot in the land of Qwen
- Source code of Swedish e-government services has been leaked
- South Korean Police Lose Seized Crypto by Posting Password Online
- Speculative Speculative Decoding (SSD)
- Speed at the cost of quality: Study of use of Cursor AI in open source projects
- Spice Data (YC S19) Is Hiring a Product Specialist
- Spotify playing ads for paid subscribers
- Standardizing source maps
- Stanford researchers report first recording of a blue whale's heart rate (2019)
- Stardex (YC S21) is hiring customer success engineers
- Statement from Dario Amodei on Our Discussions with the Department of War
- Statement from Dario Amodei on our discussions with the Department of War
- Statement on the comments from Secretary of War Pete Hegseth
- Steel Bank Common Lisp
- Stop Using Grey Text (2025)
- Storing 2 bytes of data in your Logitech mouse
- Story of XZ Backdoor [video]
- Stripe reportedly makes offer to acquire PayPal
- Stripe valued at $159B, 2025 annual letter
- Structured AI (YC F25) Is Hiring
- Sunsetting Jazzband
- Super Micro Shares Plunge 25% After Co-Founder Charged in $2.5B Smuggling Plot
- Supertoast tables
- Surpassing vLLM with a Generated Inference Stack
- Switch to Claude without starting over
- Switzerland Built an Alternative to BGP
- SynthID
- System76 on Age Verification Laws
- TADA: Fast, Reliable Speech Generation Through Text-Acoustic Synchronization
- TUI Studio – visual terminal UI design tool
- Talos: Hardware accelerator for deep convolutional neural networks
- TeX Live 2026 is available for download now
- Teaching Claude to QA a mobile app
- Tech Companies Shouldn't Be Bullied into Doing Surveillance
- Tech companies shouldn't be bullied into doing surveillance
- Tech employment now significantly worse than the 2008 or 2020 recessions
- Technical Excellence Is Not Enough
- Techno‑Feudal Elite Are Attempting to Build a Twenty‑First‑Century Fascist State
- Tell HN: Apple development certificate server seems down?
- Tell HN: I'm 60 years old. Claude Code has re-ignited a passion
- Tell HN: YC companies scrape GitHub activity, send spam emails to users
- Temporal: A nine-year journey to fix time in JavaScript
- Tenth Circuit: 4th Amendment Doesn't Support Broad Search of Protesters' Devices
- Tesla registrations crash 17% in Europe as BEV market surges 14%
- The 185-Microsecond Type Hint
- The 49MB web page
- The Accidental Room (2018)
- The Appalling Stupidity of Spotify's AI DJ
- The Appeal and Reality of Recycling LoRAs with Adaptive Merging
- The Banality of Surveillance
- The Brand Age
- The Day I Discovered Type Design
- The Enterprise Context Layer
- The Excommunicated Devs Making Games with AI
- The Future of AI
- The Future of Version Control
- The Government Uses Targeted Advertising to Track Your Location
- The Hunt for Dark Breakfast – Can we derive breakfasts we have never observed?
- The Hunt for Dark Breakfast
- The Impact of AI on Game Dev Jobs. Open to Work Crisis
- The L in "LLM" Stands for Lying
- The Life Cycle of Money
- The Linux Programming Interface as a university course text
- The Millisecond That Could Change Cancer Treatment
- The Misuses of the University
- The Most-Seen UI on the Internet? Redesigning Turnstile and Challenge Pages
- The Om Programming Language
- The Pentagon Feuding with an AI Company Is a Bad Sign
- The Pentagon Threatens Anthropic
- The Pentagon is making a mistake by threatening Anthropic
- The Reason Windows Hate Is Exploding: It's the End of Personal Computing [video]
- The Robotic Dexterity Deadlock
- The Science of Detecting LLM-Generated Text
- The Science of Detecting LLM-Generated Text (2024)
- The Shady World of IP Leasing
- The Slow Death of the Power User
- The Soul of a Pedicab Driver
- The Three Pillars of JavaScript Bloat
- The United States needs fewer bus stops
- The View from RSS
- The Webpage Has Instructions. The Agent Has Your Credentials
- The Windows 95 User Interface: A Case Study in Usability Engineering
- The Windows 95 user interface: A case study in usability engineering (1996)
- The Wyden Siren Goes Off Again: We'll Be "Stunned" by NSA Under Section 702
- The Xkcd thing, now interactive
- The beauty and terror of modding Windows
- The biggest theft in human history occurred in broad daylight
- The changing goalposts of AGI and timelines
- The complete Manic Miner disassembly
- The death of social media is the renaissance of RSS (2025)
- The first airplane fatality
- The gold standard of optimization: A look under the hood of RollerCoaster Tycoon
- The inner workings of TCP zero-copy
- The next generations of Bubble Tea, Lip Gloss, and Bubbles are available now
- The normalization of corruption in organizations (2003) [pdf]
- The pleasures of poor product design
- The return-to-the-office trend backfires
- The stagnancy of publishing and the disappearance of the midlist
- The strait of Hormuz blockade will strangle US defense industry
- The surprising whimsy of the Time Zone Database
- The war against PDFs is heating up
- The whole thing was a scam
- The workers behind Meta's smart glasses can see everything
- The workers behind Meta’s smart glasses can see everything
- The worst acquisition in history, again
- The yoghurt delivery women combatting loneliness in Japan
- The “JVG algorithm” only wins on tiny numbers
- The “small web” is bigger than you might think
- Theory of Constraints: "Blue Light" creating capacity for nothing (2007)
- Thermal Grizzly was scammed twice on raw materials worth €40k
- They're Vibe-Coding Spam Now
- Thinking Fast, Slow, and Artificial: How AI Is Reshaping Human Reasoning
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- Time Is Different
- Timeline: Anthropic, OpenAI, and U.S. Government
- Tinnitus Is Connected to Sleep
- Tinybox – Offline AI device 120B parameters
- Tom Homan confirms ICE to be at airports starting Monday
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- Tree Search Distillation for Language Models Using PPO
- Trellis AI (YC W24) is hiring deployment lead to accelerate medication access
- Turing Completeness of GNU Find: From Mkdir-Assisted Loops to Standalone Comput
- Turing Completeness of GNU find
- Turns out Generative AI was a scam
- Twitch: "Hey, come back! This commercial break can't play while you're away."
- Two Years of Emacs Solo
- Two Years of Emacs Solo: 35 Modules, Zero External Packages, and a Full Refactor
- Two insider cases we've recently closed
- U+237C ⍼ Is Azimuth
- U.S. and Israel Conduct Strikes on Iran
- U.S. science agency moves to restrict foreign scientists from its labs
- UK's Ofcom has today fined 4chan £450k for not having age checks in place
- UMD Scientists Create 'Smart Underwear' to Measure Human Flatulence
- US Court of Appeals: TOS may be updated by email, use can imply consent [pdf]
- US Court of Appeals: TOS may be updated by email, use may imply consent [pdf]
- US Military leaders meet with Anthropic to argue against Claude safeguards
- US SEC preparing to scrap quarterly reporting requirement
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- US economy sheds 92,000 jobs in February in sharp slide
- US orders diplomats to fight data sovereignty initiatives
- US private credit defaults hit record 9.2% in 2025, Fitch says
- UUID package coming to Go standard library
- Ubicloud (YC W24): Software Engineer – $95-$250K in Turkey, Netherlands, CA
- Ubuntu 26.04 Ends 46 Years of Silent sudo Passwords
- Universal vaccine against respiratory infections and allergens
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- Uploading Pirated Books via BitTorrent Qualifies as Fair Use, Meta Argues
- Urea prices
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