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Qt45: A small polymerase ribozyme that can synthesize itself
🔬 Qt45: A Breakthrough in Self-Replication. Qt45 is a small polymerase ribozyme that can synthesize itself, offering immense potential for advancements in biotechnology and synthetic biology, enabling the creation of self-replicating molecules with potential applications in fields like medicine and materials science. This innovation holds significant value for scientific research and development, promising new avenues for discovery and exploration.
1:05 am, February 28, 2026
guid
https://news.ycombinator.com/item?id=47187649
source_url
https://www.science.org/doi/10.1126/science.adt2760
author_name
ppnpm
id: 242
uid: VthK2
insdate: 2026-02-28 01:05:05
title: Qt45: A small polymerase ribozyme that can synthesize itself
additional: 🔬 Qt45: A Breakthrough in Self-Replication. Qt45 is a small polymerase ribozyme that can synthesize itself, offering immense potential for advancements in biotechnology and synthetic biology, enabling the creation of self-replicating molecules with potential applications in fields like medicine and materials science. This innovation holds significant value for scientific research and development, promising new avenues for discovery and exploration.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47187649
source_url: https://www.science.org/doi/10.1126/science.adt2760
updated:
image:
author_name: ppnpm
author_link:
uid: VthK2
insdate: 2026-02-28 01:05:05
title: Qt45: A small polymerase ribozyme that can synthesize itself
additional: 🔬 Qt45: A Breakthrough in Self-Replication. Qt45 is a small polymerase ribozyme that can synthesize itself, offering immense potential for advancements in biotechnology and synthetic biology, enabling the creation of self-replicating molecules with potential applications in fields like medicine and materials science. This innovation holds significant value for scientific research and development, promising new avenues for discovery and exploration.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47187649
source_url: https://www.science.org/doi/10.1126/science.adt2760
updated:
image:
author_name: ppnpm
author_link:
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- Little Free Library Books
- Living human brain cells play DOOM on a CL1 [video]
- LoGeR – 3D reconstruction from extremely long videos (DeepMind, UC Berkeley)
- Looks like it is happening
- Lost Doctor Who Episodes Found
- Love of corporate bullshit is correlated with bad judgment
- MAUI Is Coming to Linux
- MCP is dead. Long live the CLI
- Mac external displays for designers and developers, part 2 (2022)
- MacBook M5 Pro and Qwen3.5 = Local AI Security System
- Mac mini will be made at a new facility in Houston
- Making Firefox's right-click not suck with about:config
- Making MCP cheaper via CLI
- Making Wolfram tech available as a foundation tool for LLM systems
- Manjaro website off-line again due to lapsed certificate
- Many SWE-bench-Passing PRs would not be merged
- Measuring progress toward AGI: A cognitive framework
- Medical journal says the case reports it has published for 25 years are fiction
- Megadev: A Development Kit for the Sega Mega Drive and Mega CD Hardware
- Men in their 50s may be aging faster due to toxic 'forever chemicals'
- Mercury 2: Fast reasoning LLM powered by diffusion
- Mercury 2: The fastest reasoning LLM, powered by diffusion
- Mesh over Bluetooth LE, TCP, or Reticulum
- Meta Horizon Worlds on Meta Quest is being discontinued
- Meta and TikTok let harmful content rise to drove engagement, say whistleblowers
- Meta’s AI smart glasses and data privacy concerns
- Meta’s renewed commitment to jemalloc
- Meticulous (YC S21) is hiring to redefine software dev
- Michael Pollan punctures the AI bubble
- Microgpt
- Microslop Manifesto
- Microsoft BitNet: 100B Param 1-Bit model for local CPUs
- Microsoft Creative Writer (1993)
- Microsoft bans the word "Microslop" on its Discord, then locks the server
- Microsoft's 'unhackable' Xbox One has been hacked by 'Bliss'
- Migrating the American Express Payment Network, Twice
- Militaries are scrambling to create their own Starlink
- MinIO Is Dead, Long Live MinIO
- Mistral AI Releases Forge
- MitID, Denmarks sole digital ID, has been down for over an hour and counting
- Monkey Island for Commodore 64 Ground Up
- MonoGame: A .NET framework for making cross-platform games
- More common mistakes to avoid when creating system architecture diagrams
- Most of the US economy is in a recession
- Motorola announces a partnership with GrapheneOS Foundation
- Mouser: An open source alternative to Logi-Plus mouse software
- Mozilla to launch free built-in VPN in upcoming Firefox 149
- Mullvad VPN: Banned TV Ad in the Streets of London [video]
- Multifactor (YC F25) Is Hiring an Engineering Lead
- My Homelab Setup
- NASA announces major overhaul of Artemis program amid safety concerns, delays
- NASA announces overhaul of Artemis program amid safety concerns, delays
- NMAP in the Movies
- NRC Issues First Commercial Reactor Construction Approval in 10 Years [pdf]
- NRC issues first commercial reactor construction approval in 10 years [pdf]
- Nango (YC W23, API Access for Agents and Apps) Is Hiring
- Nano Banana 2: Google's latest AI image generation model
- NanoGPT Slowrun: Language Modeling with Limited Data, Infinite Compute
- Nasdaq's Shame
- Ndea (YC W26) is hiring a symbolic RL search guidance lead
- Nearby Glasses
- Netflix Backs Out of Warner Bros. Bidding, Paramount Set to Win
- Networking with agents: Put them in the right conversations with Tailscale
- Never Bet Against x86
- Never Buy A .online Domain
- New AirSnitch attack breaks Wi-Fi encryption in homes, offices, and enterprises
- New California law requires age verification for all OS accounts
- New York could prohibit chatbot medical, legal, engineering advice
- New accounts on HN 10x more likely to use em-dashes
- New iron nanomaterial wipes out cancer cells without harming healthy tissue
- Nightingale – open-source karaoke app that works with any song on your computer
- Nihilistic Violent Extremism
- No evidence cannabis helps anxiety, depression, or PTSD
- No right to relicense this project
- No, it doesn't cost Anthropic $5k per Claude Code user
- Nobody Gets Promoted for Simplicity
- Node.js needs a virtual file system
- Noq: n0's new QUIC implementation in Rust
- North Korean's 100k fake IT workers net $500M a year for Kim
- Notes on Baking at the South Pole
- Notes on Lagrange Interpolating Polynomials
- Notes on Writing WASM
- Number Research Inc
- Number of UK workers on zero-hours contracts hits record high ahead of crackdown
- Nvidia Launches Vera CPU, Purpose-Built for Agentic AI
- Nvidia NemoClaw
- Nvidia PersonaPlex 7B on Apple Silicon: Full-Duplex Speech-to-Speech in Swift
- Nvidia backs AI data center startup Nscale as it hits $14.6B valuation
- Obsidian Sync now has a headless client
- Office.eu launches as Europe's sovereign office platform
- Oil Is Near a Price That Hurts the Economy
- Oil nears $110 a barrel after gas field strike
- Online astroturfing: A problem beyond disinformation
- Open Letter to Google on Mandatory Developer Registration for App Distribution
- Open Source Endowment – new funding source for open source maintainers
- Open source calculator firmware DB48X forbids CA/CO use due to age verification
- OpenAI Fires an Employee for Prediction Market Insider Trading
- OpenAI agrees with Dept. of War to deploy models in their classified network
- OpenAI fires an employee for prediction market insider trading
- OpenAI is walking away from expanding its Stargate data center with Oracle
- OpenAI reaches deal to deploy AI models on U.S. DoW classified network
- OpenAI resets spending expectations, from $1.4T to $600B
- OpenAI – How to delete your account
- OpenAI's $110B funding round (investments from Amazon, Nvidia, SoftBank)
- OpenAI, the US government and Persona built an identity surveillance machine
- OpenBSD on SGI: A Rollercoaster Story
- OpenClaw Surpasses React to Become the Most-Starred Software Project on GitHub
- OpenClaw is a security nightmare dressed up as a daydream
- OpenCode – Open source AI coding agent
- OpenCode – The open source AI coding agent
- OpenSUSE Kalpa
- OpenTitan Shipping in Production
- Operational issue – Multiple services (UAE)
- Optimizing Content for Agents
- Oracle is building yesterday's data centers with tomorrow's debt
- Oregon school cell phone ban: 'Engaged students, joyful teachers'
- Origin of the rule that swap size should be 2x of the physical memory
- Osaka: Kansai Airport proud to have never lost single piece of luggage (2024)
- OsmAnd's Faster Offline Navigation
- OsmAnd's Faster Offline Navigation (2025)
- Otters as Bioindicators of Estuarine Health
- Our Agreement with the Department of War
- Our Computer Using agent just solved CAPTCHA up to Level 6
- Our Experience with I-Ready
- PA Bench: Evaluating Frontier Models on Multi-Tab Pa Tasks
- PA bench: Evaluating web agents on real world personal assistant workflows
- PC Gamer recommends RSS readers in a 37mb article that just keeps downloading
- PC processors entered the Gigahertz era today in the year 2000 with AMD's Athlon
- Packaging a Gleam app into a single executable
- Palantir extends reach into British state as gets access to sensitive FCA data
- Palantir's AI Is Playing a Major Role in Tracking Gaza Aid Deliveries
- Palm OS User Interface Guidelines (2003) [pdf]
- Palm OS User Interface Guidelines [pdf, 2003]
- Parakeet.cpp – Parakeet ASR inference in pure C++ with Metal GPU acceleration
- Parallel coding agents with tmux and Markdown specs
- Parallels confirms MacBook Neo can run Windows in a virtual machine
- Pass-Through of Tariffs: Evidence from European Wine Imports
- Passengers who refuse to use headphones can now be kicked off United flights
- Paul Brainerd, Founder of Aldus PageMaker, has died
- Pentagon chief blocks officers from Ivy League schools and top universities
- Pentagon expands oversight of Stars and Stripes, limits content
- Pentagon threatens to make Anthropic a pariah
- Personal Computer by Perplexity
- Philosoph Jürgen Habermas Gestorben
- Physicists Trace Sun's Magnetic Engine, 200k Kilometers Below Surface
- Physicists developing a quantum computer that’s entirely open source
- Physics Girl: Super-Kamiokande – Imaging the sun by detecting neutrinos [video]
- Pi – A minimal terminal coding harness
- Pi – a minimal terminal coding harness
- Plasma Bigscreen – 10-foot interface for KDE plasma
- Plastic is made from milk and it vanishes in 13 weeks
- Please do not use auto-scrolling content on the web and in applications
- Please, please, please stop using passkeys for encrypting user data
- Poll: Code with AI or Not?
- Polymarket gamblers threaten to kill me over Iran missile story
- Poor Man's Polaroid
- Porn depicting sex between step-relatives set to be banned in the UK
- Possible US Government iPhone-Hacking Toolkit in foreign spy and criminal hands
- PostmarketOS in 2026-02: generic kernels, bans use of generative AI
- Preliminary data from a longitudinal AI impact study
- President Trump bans Anthropic from use in government systems
- Privacy-preserving age and identity verification via anonymous credentials
- Process-Based Concurrency: Why Beam and OTP Keep Being Right
- Professional video editing, right in the browser with WebGPU and WASM
- Profiling Hacker News users based on their comments
- Prompt-caching – auto-injects Anthropic cache breakpoints (90% token savings)
- Proton Mail Helped FBI Unmask Anonymous 'Stop Cop City' Protester
- Psychology: Who dont maintain many close friends, learned independence too early
- Push events into a running session with channels
- Put the zip code first
- Python 3.15's JIT is now back on track
- QGIS 4.0
- Qt45: A small polymerase ribozyme that can synthesize itself
- Quillx is an open standard for disclosing AI involvement in software projects
- Qwen3.5 122B and 35B models offer Sonnet 4.5 performance on local computers
- RAM kits are now sold with one fake RAM stick alongside a real one
- RAM now represents 35 percent of bill of materials for HP PCs
- RFC 9849. TLS Encrypted Client Hello
- RISC-V Is Sloooow
- RX – a new random-access JSON alternative
- Rack-Mount Hydroponics
- Rack-mount hydroponics
- Racket v9.1
- Red Dwarf creator Rob Grant has died
- Red Hat takes on Docker Desktop with its enterprise Podman Desktop build
- Reddit User Uncovers Who Is Behind Meta's $2B Lobbying for Age Verification Tech
- Redox OS has adopted a Certificate of Origin policy and a strict no-LLM policy
- Reflex (YC W23) Is Hiring Software Engineers – Python
- Relax NG is a schema language for XML (2014)
- Reliable Software in the LLM Era
- Relicensing with AI-Assisted Rewrite
- Remotely unlocking an encrypted hard disk
- Rendezvous with Rama
- Revealed: Face of 75,000-year-old female Neanderthal from cave
- Reverse-engineering Viktor and making it Open Source
- Reversing memory loss via gut-brain communication
- Right-sizes LLM models to your system's RAM, CPU, and GPU
- Rob Grant, creator of Red Dwarf, has died
- Rob Pike's 5 Rules of Programming
- Roboflow (YC S20) Is Hiring a Security Engineer for AI Infra
- Robotocore · a Digital Twin of AWS
- Runners who churn butter on their runs
- Running a One Trillion-Parameter LLM Locally on AMD Ryzen AI Max+ Cluster
- Rust Is Just a Tool
- Rust is just a tool
- Ryugu asteroid samples contain all DNA and RNA building blocks
- SBCL Fibers – Lightweight Cooperative Threads
- SBCL: A Sanely-Bootstrappable Common Lisp (2008) [pdf]
- SIM (YC X25) Is Hiring the Best Engineers in San Francisco
- SSH has no Host header
- SWE-CI: Evaluating Agent Capabilities in Maintaining Codebases via CI
- Samsung Galaxy update removes Android recovery menu tools, including sideloading
- Sandboxes won't save you from OpenClaw
- Sarvam 105B, the first competitive Indian open source LLM
- Sashiko: An agentic Linux kernel code review system
- Scaling Karpathy's Autoresearch: What Happens When the Agent Gets a GPU Cluster
- Scientists discover a surprising way to quiet the anxious mind (2025)
- Scrt: A CLI secret manager for developers, sysadmins and DevOps
- Sea level much higher than assumed in most coastal hazard assessments
- Searching for the Agentic IDE
- Seed of Might Color Correction Process (2023) [pdf]
- Self-improving software won't produce Skynet
- Sem – Semantic version control. Entity-level diffs on top of Git
- Senior European journalist suspended over AI-generated quotes
- Separating the Wayland compositor and window manager
- Setting up OpenClaw on a cloud VM
- Shall I implement it? No
- Show HN: A context-aware permission guard for Claude Code
- Show HN: A real-time strategy game that AI agents can play
- Show HN: ANSI-Saver – A macOS Screensaver
- Show HN: Agent Swarm – Multi-agent self-learning teams (OSS)
- Show HN: Algorithms and Data Structures in TypeScript – Free Book (~400 Pages)
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- Show HN: Atomic – self-hosted, semantically-connected personal knowledge base
- Show HN: Audio Toolkit for Agents
- Show HN: Aurion OS – A 32-bit GUI operating system written from scratch in C
- Show HN: Autoresearch@home
- Show HN: Badge that shows how well your codebase fits in an LLM's context window
- Show HN: Baltic shadow fleet tracker – live AIS, cable proximity alerts
- Show HN: Better Hub – A better GitHub experience
- Show HN: Claude-File-Recovery, recover files from your ~/.claude sessions
- Show HN: Claude-replay – A video-like player for Claude Code sessions
- Show HN: Clocksimulator.com – A minimalist, distraction-free analog clock
- Show HN: Context Gateway – Compress agent context before it hits the LLM
- Show HN: Context Mode – 315 KB of MCP output becomes 5.4 KB in Claude Code
- Show HN: Curiosity – DIY 6" Newtonian Reflector Telescope
- Show HN: Decided to play god this morning, so I built an agent civilisation
- Show HN: Deff – side-by-side Git diff review in your terminal
- Show HN: Django Control Room – All Your Tools Inside the Django Admin
- Show HN: Duplicate 3 layers in a 24B LLM, logical deduction .22→.76. No training
- Show HN: Emdash – Open-source agentic development environment
- Show HN: Eyot, A programming language where the GPU is just another thread
- Show HN: Free OpenAI API Access with ChatGPT Account
- Show HN: GDSL – 800 line kernel: Lisp subset in 500, C subset in 1300
- Show HN: Gapless.js – gapless web audio playback
- Show HN: Giggles – A batteries-included React framework for TUIs
- Show HN: Global Maritime Chokepoints
- Show HN: Govbase – Follow a bill from source text to news bias to social posts
- Show HN: GrobPaint: Somewhere Between MS Paint and Paint.net
- Show HN: Han – A Korean programming language written in Rust
- Show HN: Horizon – GPU-accelerated infinite-canvas terminal in Rust
- Show HN: I Was Here – Draw on street view, others can find your drawings
- Show HN: I built 48 lightweight SVG backgrounds you can copy/paste
- Show HN: I built a real-time OSINT dashboard pulling 15 live global feeds
- Show HN: I built a site where you hire yourself instead of applying for jobs
- Show HN: I built a sub-500ms latency voice agent from scratch
- Show HN: I built a tool that watches webpages and exposes changes as RSS
- Show HN: I ported Tree-sitter to Go
- Show HN: I'm 15. I mass published 134K lines to hold AI agents accountable
- Show HN: Joonote – A note-taking app on your lock screen and notification panel
- Show HN: Klaus – OpenClaw on a VM, batteries included
- Show HN: Kula – Lightweight, self-contained Linux server monitoring tool
- Show HN: Learn Arabic with spaced repetition and comprehensible input
- Show HN: Logira – eBPF runtime auditing for AI agent runs
- Show HN: Mcp2cli – One CLI for every API, 96-99% fewer tokens than native MCP
- Show HN: Moonshine Open-Weights STT models – higher accuracy than WhisperLargev3
- Show HN: Now I Get It – Translate scientific papers into interactive webpages
- Show HN: Omni – Open-source workplace search and chat, built on Postgres
- Show HN: OneCLI – Vault for AI Agents in Rust
- Show HN: Online OCR Free – Batch OCR UI for Tesseract, Gemini and OpenRouter
- Show HN: Open-source playground to red-team AI agents with exploits published
- Show HN: OpenClaw-class agents on ESP32 (and the IDE that makes it possible)
- Show HN: OpenSwarm – Multi‑Agent Claude CLI Orchestrator for Linear/GitHub
- Show HN: Out Plane – A PaaS I built solo from Istanbul in 3 months
- Show HN: PHP 8 disable_functions bypass PoC
- Show HN: PageAgent, A GUI agent that lives inside your web app
- Show HN: Pianoterm – Run shell commands from your Piano. A Linux CLI tool
- Show HN: Playing LongTurn FreeCiv with Friends
- Show HN: Poppy – a simple app to stay intentional with relationships
- Show HN: Reclaim Flowers – A 2D physics-based "Digital Altar" protocol
- Show HN: Recursively apply patterns for pathfinding
- Show HN: Red Grid Link – peer-to-peer team tracking over Bluetooth, no servers
- Show HN: RetroTick – Run classic Windows EXEs in the browser
- Show HN: Rev-dep – 20x faster knip.dev alternative build in Go
- Show HN: Revise – An AI Editor for Documents
- Show HN: Rust-powered document chunker for RAG – 40x faster, O(1) memory
- Show HN: SNKV – SQLite's B-tree as a key-value store (C/C++ and Python bindings)
- Show HN: SQLite for Rivet Actors – one database per agent, tenant, or document
- Show HN: Sgai – Goal-driven multi-agent software dev (GOAL.md → working code)
- Show HN: SignalCend – API that resolves conflicting IoT device state in 47ms
- Show HN: Signet – Autonomous wildfire tracking from satellite and weather data
- Show HN: Simple plugin to get Claude Code to listen to you
- Show HN: Skir – like Protocol Buffer but better
- Show HN: Sonar – A tiny CLI to see and kill whatever's running on localhost
- Show HN: SplatHash – A lightweight alternative to BlurHash and ThumbHash
- Show HN: Steerling-8B, a language model that can explain any token it generates
- Show HN: Swarm – Program a colony of 200 ants using a custom assembly language
- Show HN: Terminal Phone – E2EE Walkie Talkie from the Command Line
- Show HN: Terminal-Style Portfolio on the Internet
- Show HN: The Mog Programming Language
- Show HN: The Roman Industrial Revolution that could have been (Vol 2)
- Show HN: Timber – Ollama for classical ML models, 336x faster than Python
- Show HN: Tmux-IDE, OSS agent-first terminal IDE
- Show HN: Tomoshibi – A writing app where your words fade by firelight
- Show HN: Trackm, a personal finance web app
- Show HN: Understudy – Teach a desktop agent by demonstrating a task once
- Show HN: VS Code Agent Kanban: Task Management for the AI-Assisted Developer
- Show HN: Vanilla JavaScript refinery simulator built to explain job to my kids
- Show HN: Vertex.js – A 1kloc SPA Framework
- Show HN: We built a terminal-only Bluesky / AT Proto client written in Fortran
- Show HN: Web Audio Studio – A Visual Debugger for Web Audio API Graphs
- Show HN: Will my flight have Starlink?
- Show HN: X86CSS – An x86 CPU emulator written in CSS
- Show HN: Xmloxide – an agent made rust replacement for libxml2
- Show HN: ZSE – Open-source LLM inference engine with 3.9s cold starts
- Show HN: enveil – hide your .env secrets from prAIng eyes
- Show HN: fftool – A Terminal UI for FFmpeg – Shows Command Before It Runs
- Show HN: s@: decentralized social networking over static sites
- Show HN: uBlock filter list to blur all Instagram Reels
- SigNoz (YC W21, open source Datadog) Is Hiring across roles
- Smalltalk's Browser: Unbeatable, yet Not Enough
- Smartphone Mkt to Decline 13% in '26, Largest Drop Ever Due to Memory Shortage
- Smartphone market forecast to decline this year due to memory shortage
- So you want to write an “app” (2025)
- Software 3.1? – AI Functions
- Some Things Just Take Time
- Someone Needs to Go to Jail
- Something is afoot in the land of Qwen
- Source code of Swedish e-government services has been leaked
- South Korean Police Lose Seized Crypto by Posting Password Online
- Speculative Speculative Decoding (SSD)
- Speed at the cost of quality: Study of use of Cursor AI in open source projects
- Spice Data (YC S19) Is Hiring a Product Specialist
- Spotify playing ads for paid subscribers
- Standardizing source maps
- Stanford researchers report first recording of a blue whale's heart rate (2019)
- Stardex (YC S21) is hiring customer success engineers
- Statement from Dario Amodei on Our Discussions with the Department of War
- Statement from Dario Amodei on our discussions with the Department of War
- Statement on the comments from Secretary of War Pete Hegseth
- Steel Bank Common Lisp
- Stop Using Grey Text (2025)
- Storing 2 bytes of data in your Logitech mouse
- Story of XZ Backdoor [video]
- Stripe reportedly makes offer to acquire PayPal
- Stripe valued at $159B, 2025 annual letter
- Structured AI (YC F25) Is Hiring
- Sunsetting Jazzband
- Super Micro Shares Plunge 25% After Co-Founder Charged in $2.5B Smuggling Plot
- Supertoast tables
- Surpassing vLLM with a Generated Inference Stack
- Switch to Claude without starting over
- Switzerland Built an Alternative to BGP
- SynthID
- System76 on Age Verification Laws
- TADA: Fast, Reliable Speech Generation Through Text-Acoustic Synchronization
- TUI Studio – visual terminal UI design tool
- Talos: Hardware accelerator for deep convolutional neural networks
- TeX Live 2026 is available for download now
- Teaching Claude to QA a mobile app
- Tech Companies Shouldn't Be Bullied into Doing Surveillance
- Tech companies shouldn't be bullied into doing surveillance
- Tech employment now significantly worse than the 2008 or 2020 recessions
- Technical Excellence Is Not Enough
- Techno‑Feudal Elite Are Attempting to Build a Twenty‑First‑Century Fascist State
- Tell HN: Apple development certificate server seems down?
- Tell HN: I'm 60 years old. Claude Code has re-ignited a passion
- Tell HN: YC companies scrape GitHub activity, send spam emails to users
- Temporal: A nine-year journey to fix time in JavaScript
- Tenth Circuit: 4th Amendment Doesn't Support Broad Search of Protesters' Devices
- Tesla registrations crash 17% in Europe as BEV market surges 14%
- The 185-Microsecond Type Hint
- The 49MB web page
- The Accidental Room (2018)
- The Appalling Stupidity of Spotify's AI DJ
- The Appeal and Reality of Recycling LoRAs with Adaptive Merging
- The Banality of Surveillance
- The Brand Age
- The Day I Discovered Type Design
- The Enterprise Context Layer
- The Excommunicated Devs Making Games with AI
- The Future of AI
- The Future of Version Control
- The Government Uses Targeted Advertising to Track Your Location
- The Hunt for Dark Breakfast – Can we derive breakfasts we have never observed?
- The Hunt for Dark Breakfast
- The Impact of AI on Game Dev Jobs. Open to Work Crisis
- The L in "LLM" Stands for Lying
- The Life Cycle of Money
- The Linux Programming Interface as a university course text
- The Millisecond That Could Change Cancer Treatment
- The Misuses of the University
- The Most-Seen UI on the Internet? Redesigning Turnstile and Challenge Pages
- The Om Programming Language
- The Pentagon Feuding with an AI Company Is a Bad Sign
- The Pentagon Threatens Anthropic
- The Pentagon is making a mistake by threatening Anthropic
- The Reason Windows Hate Is Exploding: It's the End of Personal Computing [video]
- The Robotic Dexterity Deadlock
- The Science of Detecting LLM-Generated Text
- The Science of Detecting LLM-Generated Text (2024)
- The Shady World of IP Leasing
- The Slow Death of the Power User
- The Soul of a Pedicab Driver
- The Three Pillars of JavaScript Bloat
- The United States needs fewer bus stops
- The View from RSS
- The Webpage Has Instructions. The Agent Has Your Credentials
- The Windows 95 User Interface: A Case Study in Usability Engineering
- The Windows 95 user interface: A case study in usability engineering (1996)
- The Wyden Siren Goes Off Again: We'll Be "Stunned" by NSA Under Section 702
- The Xkcd thing, now interactive
- The beauty and terror of modding Windows
- The biggest theft in human history occurred in broad daylight
- The changing goalposts of AGI and timelines
- The complete Manic Miner disassembly
- The death of social media is the renaissance of RSS (2025)
- The first airplane fatality
- The gold standard of optimization: A look under the hood of RollerCoaster Tycoon
- The inner workings of TCP zero-copy
- The next generations of Bubble Tea, Lip Gloss, and Bubbles are available now
- The normalization of corruption in organizations (2003) [pdf]
- The pleasures of poor product design
- The return-to-the-office trend backfires
- The stagnancy of publishing and the disappearance of the midlist
- The strait of Hormuz blockade will strangle US defense industry
- The surprising whimsy of the Time Zone Database
- The war against PDFs is heating up
- The whole thing was a scam
- The workers behind Meta's smart glasses can see everything
- The workers behind Meta’s smart glasses can see everything
- The worst acquisition in history, again
- The yoghurt delivery women combatting loneliness in Japan
- The “JVG algorithm” only wins on tiny numbers
- The “small web” is bigger than you might think
- Theory of Constraints: "Blue Light" creating capacity for nothing (2007)
- Thermal Grizzly was scammed twice on raw materials worth €40k
- They're Vibe-Coding Spam Now
- Thinking Fast, Slow, and Artificial: How AI Is Reshaping Human Reasoning
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- Time Is Different
- Timeline: Anthropic, OpenAI, and U.S. Government
- Tinnitus Is Connected to Sleep
- Tinybox – Offline AI device 120B parameters
- Tom Homan confirms ICE to be at airports starting Monday
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- Tree Search Distillation for Language Models Using PPO
- Trellis AI (YC W24) is hiring deployment lead to accelerate medication access
- Turing Completeness of GNU Find: From Mkdir-Assisted Loops to Standalone Comput
- Turing Completeness of GNU find
- Turns out Generative AI was a scam
- Twitch: "Hey, come back! This commercial break can't play while you're away."
- Two Years of Emacs Solo
- Two Years of Emacs Solo: 35 Modules, Zero External Packages, and a Full Refactor
- Two insider cases we've recently closed
- U+237C ⍼ Is Azimuth
- U.S. and Israel Conduct Strikes on Iran
- U.S. science agency moves to restrict foreign scientists from its labs
- UK's Ofcom has today fined 4chan £450k for not having age checks in place
- UMD Scientists Create 'Smart Underwear' to Measure Human Flatulence
- US Court of Appeals: TOS may be updated by email, use can imply consent [pdf]
- US Court of Appeals: TOS may be updated by email, use may imply consent [pdf]
- US Military leaders meet with Anthropic to argue against Claude safeguards
- US SEC preparing to scrap quarterly reporting requirement
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- US economy sheds 92,000 jobs in February in sharp slide
- US orders diplomats to fight data sovereignty initiatives
- US private credit defaults hit record 9.2% in 2025, Fitch says
- UUID package coming to Go standard library
- Ubicloud (YC W24): Software Engineer – $95-$250K in Turkey, Netherlands, CA
- Ubuntu 26.04 Ends 46 Years of Silent sudo Passwords
- Universal vaccine against respiratory infections and allergens
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- Uploading Pirated Books via BitTorrent Qualifies as Fair Use, Meta Argues
- Urea prices
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