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Peptides: where to begin?
Peptide Tech 🤖
Peptides are short chains of amino acids, offering versatile applications in medicine, research, and diagnostics, enabling targeted therapies and biomarker development. Their unique properties make them valuable for studying protein interactions, disease mechanisms, and developing new treatments. Peptides provide a promising avenue for advancing personalized medicine and understanding complex biological processes.
8:05 am, April 7, 2026
guid
https://news.ycombinator.com/item?id=47667321
source_url
https://www.science.org/content/blog-post/ah-peptides-where-begin
author_name
A_D_E_P_T
id: 1572
uid: TynMW
insdate: 2026-04-07 08:05:31
title: Peptides: where to begin?
additional:
Peptides are short chains of amino acids, offering versatile applications in medicine, research, and diagnostics, enabling targeted therapies and biomarker development. Their unique properties make them valuable for studying protein interactions, disease mechanisms, and developing new treatments. Peptides provide a promising avenue for advancing personalized medicine and understanding complex biological processes.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47667321
source_url: https://www.science.org/content/blog-post/ah-peptides-where-begin
updated:
image:
author_name: A_D_E_P_T
author_link:
uid: TynMW
insdate: 2026-04-07 08:05:31
title: Peptides: where to begin?
additional:
Peptide Tech 🤖
Peptides are short chains of amino acids, offering versatile applications in medicine, research, and diagnostics, enabling targeted therapies and biomarker development. Their unique properties make them valuable for studying protein interactions, disease mechanisms, and developing new treatments. Peptides provide a promising avenue for advancing personalized medicine and understanding complex biological processes.
category: Hacker News
md5:
guid: https://news.ycombinator.com/item?id=47667321
source_url: https://www.science.org/content/blog-post/ah-peptides-where-begin
updated:
image:
author_name: A_D_E_P_T
author_link:
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- GitHub appears to be struggling with measly three nines availability
- GitHub backs down, kills Copilot pull-request ads after backlash
- GitHub is once again down
- GitHub's Historic Uptime
- Go hard on agents, not on your filesystem
- Go is the best language for agents
- Go on Embedded Systems and WebAssembly
- GoGoGrandparent (YC S16) is hiring Back end Engineers
- Gold overtakes U.S. Treasuries as the largest foreign reserve asset
- Good code will still win
- Goodbye InnerHTML, Hello SetHTML: Stronger XSS Protection in Firefox 148
- Goodbye to Sora
- Google API Keys Weren't Secrets. But Then Gemini Changed the Rules
- Google API keys weren't secrets, but then Gemini changed the rules
- Google Engineers Launch "Sashiko" for Agentic AI Code Review of the Linux Kernel
- Google Street View in 2026
- Google Workers Seek 'Red Lines' on Military A.I., Echoing Anthropic
- Google Workspace CLI
- Google adds 24-hour wait and mandatory reboot to Android sideloading flow
- Google just gave Android power users a sideloading win
- Google just gave Sundar Pichai a $692M pay package
- Google removes "Doki Doki Literature Club" from Google Play
- Google's 200M-parameter time-series foundation model with 16k context
- Government agencies buy commercial data about Americans in bulk
- Government grant-funded research should not be published in for-profit journals
- Grace Hopper's Revenge
- Grafeo – A fast, lean, embeddable graph database built in Rust
- Grandparents are glued to their phones, families are worried [video]
- GrapheneOS will remain usable by anyone without requiring personal information
- Graphics Programming Resources
- Great at gaming? US air traffic control wants you to apply
- Grief and the AI split
- GrobPaint: Somewhere Between MS Paint and Paint.net. Multiplatform by Default
- Gvisor on Raspbian
- H.264 Streaming Fees: What Changed, Who's Affected, and What It Means
- HBO Obtains DMCA Subpoena to Unmask 'Euphoria' Spoiler Account on X
- HD Audio Driver for Windows 98SE / Me
- HP trialed mandatory 15-minute support call wait times (2025)
- Hacker mints $80M USD worth of USR stablecoins
- HackerRank (YC S11) Is Hiring
- Hacking an old Kindle to display bus arrival times
- Hamilton-Jacobi-Bellman Equation: Reinforcement Learning and Diffusion Models
- Hammerspoon
- HandyMKV for MakeMKV and HandBrake Automation
- Hardening Firefox with Anthropic's Red Team
- Haunt, the 70s text adventure game, is now playable on a website
- Have a Fucking Website
- Have a fucking website
- Having Kids (2019)
- Hazardous substances found in all headphones tested by ToxFREE project
- He saw an abandoned trailer. Then, uncovered a surveillance network
- Health NZ staff told to stop using ChatGPT to write clinical notes
- Hegel, a universal property-based testing protocol and family of PBT libraries
- Helix: A post-modern text editor
- Helsinki just went a full year without a single traffic death
- High-Level Rust: Getting 80% of the Benefits with 20% of the Pain
- Hightouch (YC S19) Is Hiring
- Hold on to Your Hardware
- HopTab–free,open source macOS app switcher and tiler that replaces Cmd+Tab
- Hormuz Minesweeper – Are you tired of winning?
- Hostile Volume – A game about adjusting volume with intentionally bad UI
- How AI skills are quietly automating my workday
- How BYD Got EV Chargers to Work Almost as Fast as Gas Pumps
- How I write software with LLMs
- How I'm Productive with Claude Code
- How Kernel Anti-Cheats Work
- How Lego builds a new Lego set
- How Pizza Tycoon simulated traffic on a 25 MHz CPU
- How We Broke Top AI Agent Benchmarks: And What Comes Next
- How We Synchronized Editing for Rec Room's Multiplayer Scripting System
- How Will OpenAI Compete?
- How a dancer with ALS used brainwaves to perform live
- How do I cancel my ChatGPT subscription?
- How many products does Microsoft have named 'Copilot'?
- How much precision can you squeeze out of a table?
- How the AI Bubble Bursts
- How the Government Deceived Congress in the Debate over Surveillance Powers (2013)
- How the Sriracha guys screwed over their supplier
- How to Build Your Own Quantum Computer
- How to Not Pay Your Taxes
- How to Record and Retrieve Anything You've Ever Had to Look Up Twice
- How to Write Unmaintainable Code (1999)
- How to breathe in fewer microplastics in your home
- How to build a `Git diff` driver
- How to install and start using LineageOS on your phone
- How to record and retrieve anything you've ever had to look up twice
- How to run Qwen 3.5 locally
- How to talk to anyone and why you should
- How we rebuilt Next.js with AI in one week
- How will OpenAI compete?
- Hubble Snaps a New Dazzling Photo of the Crab Nebula
- HuggingFace Agent Skills
- Hugo's New CSS Powers
- Human Rights Watch says drone strikes in Haiti have killed nearly 1,250 people
- Hybrid Attention
- Hydroph0bia – a fixed SecureBoot bypass for UEFI firmware based on Insyde H2O
- Hydroph0bia – fixed SecureBoot bypass for UEFI firmware from Insyde H2O (2025)
- Hyperlinks in Terminal Emulators
- Hypura – A storage-tier-aware LLM inference scheduler for Apple Silicon
- I Built a Scheme Compiler with AI in 4 Days
- I Built an Open-World Engine for the N64 [video]
- I Decompiled the White House's New App
- I Found 39 Algolia Admin Keys Exposed Across Open Source Documentation Sites
- I Pitched a Roller Coaster to Disneyland at Age 10 in 1978
- I Ported Coreboot to the ThinkPad X270
- I Quit. The Clankers Won
- I Traced My Traffic Through a Home Tailscale Exit Node
- I am directing the Department of War to designate Anthropic a Supply-Chain Risk
- I am directing the Department of War to designate Anthropic a supply-chain risk
- I beg you to follow Crocker's Rules, even if you will be rude to me
- I built a demo of what AI chat will look like when it's "free" and ad-supported
- I built a pint-sized Macintosh
- I built a programming language using Claude Code
- I built a tool to let you export your X bookmarks and categorize them
- I decompiled the White House's new app
- I don't know how you get here from "predict the next word."
- I found 39 Algolia admin keys exposed across open source documentation sites
- I pitched a roller coaster to Disneyland at age 10 in 1978
- I ported Linux to the PS5 and turned it into a Steam Machine
- I ported Mac OS X to the Nintendo Wii
- I put all 8,642 Spanish laws in Git – every reform is a commit
- I put my whole life into a single database
- I ran Gemma 4 as a local model in Codex CLI
- I resigned from OpenAI
- I run multiple $10K MRR companies on a $20/month tech stack
- I still prefer MCP over skills
- I think WebRTC is better than SSH-ing for connecting to Mac terminal from iPhone
- I traced $2B in grants and 45 states' lobbying behind age‑verification bills
- I tried Karpathy's Autoresearch on an old research project
- I tried to prove I'm not AI. My aunt wasn't convinced
- I use excalidraw to manage my diagrams for my blog
- I wanted to build vertical SaaS for pest control, so I took a technician job
- I'm helping my dog vibe code games
- I'm reluctant to verify my identity or age for any online services
- I've been waiting over a month for Anthropic support to respond
- I've been waiting over a month for Anthropic to respond to my billing issue
- IBM 3270 Information Display System: Color and Programmed Symbols (1979) [pdf]
- IBM Announces Strategic Collaboration with Arm
- IBM, sonic delay lines, and the history of the 80×24 display
- IPv6 address, as a sentence you can remember
- IRIX 3dfx Voodoo driver and glide2x IRIX port
- IRS Tactics Against Meta Open a New Front in the Corporate Tax Fight
- ISBN Visualization
- If AI writes code, should the session be part of the commit?
- If DSPy is so great, why isn't anyone using it?
- If you thought the code writing speed was your problem; you have bigger problems
- If you're running OpenClaw, you probably got hacked in the last week
- Iguanaworks has closed down. USB Infrared hardware open source maker
- Illinois Introducing Operating System Account Age Bill
- Image generation models can think
- Implementing automatic eSIM installation on Android
- In 2025, Meta paid an effective federal tax rate of 3.5%
- In Edison’s Revenge, Data Centers Are Transitioning From AC to DC
- In Japan, the robot isn't coming for your job; it's filling the one nobody wants
- In Memoriam: John W. Addison, my PhD advisor
- In Praise of Stupid Questions
- Incident March 30th, 2026 – Accidental CDN Caching
- Indefinite Book Club Hiatus
- Independent Geophysical Forensic Analysis of the Nordstream Pipeline Sabotage
- India's top court angry after junior judge cites fake AI-generated orders
- Inferring Car Movement Patterns from Passive TPMS Measurements
- Inferring car movement patterns from passive TPMS measurements
- Innocent woman jailed after being misidentified using AI facial recognition
- InpharmD (YC W21) Is Hiring – Senior Ruby on Rails Developer
- Inside Nepal's Fake Rescue Racket
- InspectMind AI (YC W24) Is Hiring
- Installing Every* Firefox Extension
- Installing OpenBSD on the Pomera DM250{,XY?}
- Installing a Let's Encrypt TLS Certificate on a Brother Printer with Certbot
- Installing every* Firefox extension
- Intel 486 CPU announced April 10, 1989
- Intel Announces Arc Pro B70 and Arc Pro B65 GPUs
- Intel Foundry boss leaves for Qualcomm
- Intel XeSS 3: expanded support for Core Ultra/Core Ultra 2 and Arc A, B series
- Intel's make-or-break 18A process node debuts for data center with 288-core Xeon
- Intelligence is a commodity. Context is the real AI Moat
- Intent-Based Commits
- Internet outage in Iran reaches 1,008 hours
- Interoperability Can Save the Open Web (2023)
- Intuitions for Tranformer Circuits
- Investigating How Long-Distance Couples Use Digital Games to Facilitate Intimacy
- Iran launched unsuccessful attack on UK's Diego Garcia
- Iran strikes leave Amazon availability zones "hard down" in Bahrain and Dubai
- Iran war energy shock sparks global push to reduce fossil fuel dependence
- Iran war wreaking havoc on shipping and air cargo, could create global delays
- Iran's Ayatollah Ali Khamenei is killed in Israeli strike, ending 36-year rule
- Iran's attacks on Amazon data centers in UAE, Bahrain signal a new kind of war
- Iran-backed hackers claim wiper attack on medtech firm Stryker
- Iran-linked hackers have breached FBI director's personal emails
- Ireland shuts last coal plant, becomes 15th coal-free country in Europe (2025)
- Is Germany's gold safe in New York ?
- Is anybody else bored of talking about AI?
- Is it a pint?
- Isotopic Evidence for a Cold and Distant Origin of Interstellar Object 3I/Atlas
- Israel launches strike against Iran, declares state of emergency across country
- It looks like the “JVG algorithm” only wins on tiny numbers
- Italo Calvino: A Traveller in a World of Uncertainty
- Italo Calvino: A traveller in a world of uncertainty
- JSIR: A High-Level IR for JavaScript
- JSLinux Now Supports x86_64
- JSON Formatter Chrome Plugin Now Closed and Injecting Adware
- Jack Dorsey says Block employees now bring prototypes, not slides, to meetings
- Jails for NetBSD – Kernel Enforced Isolation and Native Resource Control
- Jane Street Hit with Terra $40B Insider Trading Suit
- January in Servo: preloads, better forms, details styling, and more
- Java 26 is here
- Java is fast, code might not be
- Jazz CRJ9 at New York on Mar 22nd 2026, collision with fire truck on runway
- Jeff Bezos Upended the Washington Post
- Jemalloc un-abandoned by Meta
- Jennifer Aniston and Friends Cost Us 377GB and Broke Ext4 Hardlinks
- Jensen Huang says Nvidia is pulling back from OpenAI and Anthropic
- Jepsen: MariaDB Galera Cluster 12.1.2
- Jiga (YC W21) Is Hiring
- Jimi Hendrix was a systems engineer
- John Carmack about open source and anti-AI activists
- John Deere to pay $99M in right-to-repair settlement
- Jolla on track to ship new phone with Sailfish OS, user-replaceable battery
- Jolla phone – a full-stack European alternative
- Judge blocks Pentagon effort to 'punish' Anthropic with supply chain risk label
- Judge finalizes order for Greenpeace to pay $345M in ND oil pipeline case
- Jury says Meta knowingly harmed children for profit, awarding landmark verdict
- Just two days of oatmeal cut bad cholesterol by 10%
- Kagi Product Tips – Customize Your Search Results with URL Redirects
- Kagi Small Web
- Kagi Translate now supports LinkedIn Speak as an output language
- Kaizen (YC P25) Hiring Eng, GTM, Cos to Automate BPOs
- Kangina
- Kansai Airport has never lost a baggage in the 30 years since it opened
- Keeping a Postgres Queue Healthy
- Khamenei Dead
- Ki Editor - an editor that operates on the AST
- Kin: Semantic version control that tracks code as entities, not files
- Kyber (YC W23) Is Hiring an Enterprise Account Executive
- LLM Writing Tropes.md
- LLM plays an 8-bit Commander X16 game using structured "smart senses"
- LLM=True
- LLMs can be exhausting
- LLMs can unmask pseudonymous users at scale with surprising accuracy
- LLMs work best when the user defines their acceptance criteria first
- Labor market impacts of AI: A new measure and early evidence
- Lago (YC S21) Is Hiring
- Landmark L.A. jury verdict finds Instagram, YouTube were designed to addict kids
- Language Model Contains Personality Subnetworks
- Language Model Teams as Distrbuted Systems
- Language model teams as distributed systems
- Larry Page has moved to Florida
- Last gasps of the rent seeking class?
- Lat.md: Agent Lattice: a knowledge graph for your codebase, written in Markdown
- Latency numbers every programmer should know
- Launch HN: Captain (YC W26) – Automated RAG for Files
- Launch HN: Cardboard (YC W26) – Agentic video editor
- Launch HN: Cekura (YC F24) – Testing and monitoring for voice and chat AI agents
- Launch HN: Chamber (YC W26) – An AI Teammate for GPU Infrastructure
- Launch HN: Didit (YC W26) – Stripe for Identity Verification
- Launch HN: Freestyle: Sandboxes for AI Coding Agents
- Launch HN: IonRouter (YC W26) – High-throughput, low-cost inference
- Launch HN: Kita (YC W26) – Automate credit review in emerging markets
- Launch HN: OctaPulse (YC W26) – Robotics and computer vision for fish farming
- Launch HN: Palus Finance (YC W26): Better yields on idle cash for startups, SMBs
- Launch HN: Prism (YC X25) – Workspace and API to generate and edit videos
- Launch HN: Relvy (YC F24) – On-call runbooks, automated
- Launch HN: RunAnywhere (YC W26) – Faster AI Inference on Apple Silicon
- Launch HN: Sentrial (YC W26) – Catch AI Agent Failures Before Your Users Do
- Launch HN: Sitefire (YC W26) – Automating actions to improve AI visibility
- Launch HN: TeamOut (YC W22) – AI agent for planning company events
- Launch HN: Terminal Use (YC W26) – Vercel for filesystem-based agents
- Launch HN: Vela (YC W26) – AI for complex scheduling
- Launch HN: Voltair (YC W26) – Drone and charging network for power utilities
- Launch HN: Voygr (YC W26) – A better maps API for agents and AI apps
- Launch an autonomous AI agent with sandboxed execution in 2 lines of code
- Launching the Claude Partner Network
- Lawmakers say US Military used laser to take down Border Protection drone in TX
- Layoffs at Block
- Leanstral: Open-source agent for trustworthy coding and formal proof engineering
- Learn Claude Code by doing, not reading
- Learning Creative Coding
- Learning athletic humanoid tennis skills from imperfect human motion data
- Learnings from paying artists royalties for AI-generated art
- Leaving Google has actively improved my life
- Lemonade by AMD: a fast and open source local LLM server using GPU and NPU
- Lenovo's New ThinkPads Score 10/10 for Repairability
- Let's Get Physical
- Let's discuss sandbox isolation
- LibreOffice Writer now supports Markdown
- LibreOffice and the Art of Overreacting
- LibreOffice – Let's put an end to the speculation
- LibreSprite – open-source pixel art editor
- Libxml2 Enterprise Edition (AGPL, from the previous maintainer)
- Lichess and Take Take Take Sign Cooperation Agreement
- Lil Finder Guy
- Lil' Fun Langs' Guts
- LinkedIn uses 2.4 GB RAM across two tabs
- Linux Applications Programming by Example: The Fundamental APIs (2nd Edition)
- Linux Internals: How /proc/self/mem writes to unwritable memory (2021)
- Linux is an interpreter
- Lisette a little language inspired by Rust that compiles to Go
- Lisp-style C++ template meta programming
- LiteLLM (YC W23): Founding Reliability Engineer – $200K-$270K and 0.5-1.0% equity
- Little Free Library
- Little Free Library Books
- Little Snitch comes to Linux, but the core logic is closed source
- Little Snitch for Linux – Because Nothing Else Came Close
- LittleSnitch for Linux
- Living human brain cells play DOOM on a CL1 [video]
- LoGeR – 3D reconstruction from extremely long videos (DeepMind, UC Berkeley)
- Local Stack Archived their GitHub repo and requires an account to run
- Log File Viewer for the Terminal
- Londoners are sick of viral videos telling lies about their city
- Looks like it is happening
- Lost Doctor Who Episodes Found
- Love of corporate bullshit is correlated with bad judgment
- Lower Price for ChatGPT Business
- MAUI Is Coming to Linux
- MCP is dead. Long live the CLI
- Mac external displays for designers and developers, part 2 (2022)
- MacBook M5 Pro and Qwen3.5 = Local AI Security System
- Mac mini will be made at a new facility in Houston
- Mad Bugs: Vim vs. Emacs vs. Claude
- MagicAudio – Free Noise, Echo and Background Music Remover
- Make macOS consistently bad (unironically)
- Make macOS consistently bad unironically
- Making Firefox's right-click not suck with about:config
- Making MCP cheaper via CLI
- Making Wolfram tech available as a foundation tool for LLM systems
- Manjaro website off-line again due to lapsed certificate
- Many African families spend fortunes burying their dead
- Many SWE-bench-Passing PRs would not be merged
- Mario and Earendil
- Mathematical methods and human thought in the age of AI
- Mbodi AI (YC P25) Is Hiring
- Measuring progress toward AGI: A cognitive framework
- Media scraper Gallery-dl is moving to Codeberg after receiving a DMCA notice
- Medical journal says the case reports it has published for 25 years are fiction
- MegaTrain: Full Precision Training of 100B+ Parameter LLMs on a Single GPU
- Megadev: A Development Kit for the Sega Mega Drive and Mega CD Hardware
- Memo: A language that remembers only the last 12 lines of code
- Men in their 50s may be aging faster due to toxic 'forever chemicals'
- Meow.camera
- Mercurial Dyson – a plan for the disassembly of planet Mercury
- Mercury 2: Fast reasoning LLM powered by diffusion
- Mercury 2: The fastest reasoning LLM, powered by diffusion
- Mesh over Bluetooth LE, TCP, or Reticulum
- Meta Horizon Worlds on Meta Quest is being discontinued
- Meta and Google found liable in social media addiction trial
- Meta and TikTok let harmful content rise to drove engagement, say whistleblowers
- Meta and YouTube Found Negligent in Landmark Social Media Addiction Case
- Meta ordered to pay $375M in New Mexico trial over child exploitation
- Meta removes ads for social media addiction litigation
- Meta told to pay $375M for misleading users over child safety
- Meta’s AI smart glasses and data privacy concerns
- Meta’s renewed commitment to jemalloc
- Meticulous (YC S21) is hiring to redefine software dev
- Miasma: A tool to trap AI web scrapers in an endless poison pit
- Michael Pollan punctures the AI bubble
- Microgpt
- Microslop Manifesto
- Microsoft BitNet: 100B Param 1-Bit model for local CPUs
- Microsoft Creative Writer (1993)
- Microsoft PhotoDNA scanning problem
- Microsoft bans the word "Microslop" on its Discord, then locks the server
- Microsoft blocks trick to unlock native NVMe driver, but workarounds still exist
- Microsoft is employing dark patterns to goad users into paying for storage?
- Microsoft's "Fix" for Windows 11: Flowers After the Beating
- Microsoft's 'unhackable' Xbox One has been hacked by 'Bliss'
- Midnight Captain – A midnight commander inspired file manager
- Midnight train from GA: A view of America from the tracks as airports struggle
- Migrating the American Express Payment Network, Twice
- Migrating to the EU
- Militaries are scrambling to create their own Starlink
- MinIO Is Dead, Long Live MinIO
- MiniStack (replacement for LocalStack)
- Ministack (Replacement for LocalStack)
- Mistral AI Releases Forge
- MitID, Denmarks sole digital ID, has been down for over an hour and counting
- Modern SQLite: Features You Didn't Know It Had
- Monkey Island for Commodore 64 Ground Up
- MonoGame: A .NET framework for making cross-platform games
- More common mistakes to avoid when creating system architecture diagrams
- Most of the US economy is in a recession
- Motorola announces a partnership with GrapheneOS Foundation
- Mouser: An open source alternative to Logi-Plus mouse software
- Moving from GitHub to Codeberg, for lazy people
- Moving from WordPress to Jekyll (and static site generators in general)
- Mozilla to launch free built-in VPN in upcoming Firefox 149
- Mr. Chatterbox is a Victorian-era ethically trained model
- Mullvad VPN: Banned TV Ad in the Streets of London [video]
- Multifactor (YC F25) Is Hiring an Engineering Lead
- Muse Spark: Scaling towards personal superintelligence
- Musketeer d'Artagnan's remains believed found under Dutch church
- My Homelab Setup
- My minute-by-minute response to the LiteLLM malware attack
- NASA Artemis II moon mission live launch broadcast
- NASA announces major overhaul of Artemis program amid safety concerns, delays
- NASA announces overhaul of Artemis program amid safety concerns, delays
- NHS staff refusing to use FDP over Palantir ethical concerns
- NMAP in the Movies
- NRC Issues First Commercial Reactor Construction Approval in 10 Years [pdf]
- NRC issues first commercial reactor construction approval in 10 years [pdf]
- Naming rights to street auctioned in San Francisco
- Nango (YC W23, API Access for Agents and Apps) Is Hiring
- Nano Banana 2: Google's latest AI image generation model
- NanoClaw's Architecture Is a Masterclass in Doing Less
- NanoGPT Slowrun: Language Modeling with Limited Data, Infinite Compute
- Nasdaq's Shame
- Native Instant Space Switching on macOS
- Ndea (YC W26) is hiring a symbolic RL search guidance lead
- Neanderthals survived on a knife's edge for 350k years
- Nearby Glasses
- Neovim 0.12.0
- Nestlé says 413,793 KitKat candy bars stolen en route from Italy to Poland
- Netflix Backs Out of Warner Bros. Bidding, Paramount Set to Win
- Netscape News Feed Straight Out of the Late 00s
- Networking with agents: Put them in the right conversations with Tailscale
- Never Bet Against x86
- Never Buy A .online Domain
- New AirSnitch attack breaks Wi-Fi encryption in homes, offices, and enterprises
- New Apple Silicon M4 and M5 HiDPI Limitation on 4K External Displays
- New California law requires age verification for all OS accounts
- New Washington state law bans noncompete agreements
- New York could prohibit chatbot medical, legal, engineering advice
- New accounts on HN 10x more likely to use em-dashes
- New iron nanomaterial wipes out cancer cells without harming healthy tissue
- New laws to make it easier to cancel subscriptions and get refunds
- New synthesis of astronomical measurements shows Hubble tension is real
- Nightingale – open-source karaoke app that works with any song on your computer
- Nihilistic Violent Extremism
- No Terms. No Conditions
- No evidence cannabis helps anxiety, depression, or PTSD
- No one is happy with NASA's new idea for private space stations
- No one owes you supply-chain security
- No right to relicense this project
- No, it doesn't cost Anthropic $5k per Claude Code user
- Nobody Gets Promoted for Simplicity
- Node.js needs a virtual file system
- Noq: n0's new QUIC implementation in Rust
- North Korean's 100k fake IT workers net $500M a year for Kim
- Notes on Baking at the South Pole
- Notes on Lagrange Interpolating Polynomials
- Notes on Writing WASM
- Nowhere Is Safe
- Nowhere is safe
- Number Research Inc
- Number in man page titles e.g. sleep(3)
- Number of UK workers on zero-hours contracts hits record high ahead of crackdown
- Nvidia Launches Vera CPU, Purpose-Built for Agentic AI
- Nvidia NemoClaw
- Nvidia PersonaPlex 7B on Apple Silicon: Full-Duplex Speech-to-Speech in Swift
- Nvidia backs AI data center startup Nscale as it hits $14.6B valuation
- OCR for construction documents does not work, we fixed it
- Obsidian Sync now has a headless client
- Obsolete Sounds
- Office.eu launches as Europe's sovereign office platform
- Oil Is Near a Price That Hurts the Economy
- Oil nears $110 a barrel after gas field strike
- OkCupid gave 3M dating-app photos to facial recognition firm, FTC says
- Ollama is now powered by MLX on Apple Silicon in preview
- Olympic Committee bars transgender athletes from women’s events
- One item purchased, ten emails
- Online astroturfing: A problem beyond disinformation
- Open Letter to Google on Mandatory Developer Registration for App Distribution
- Open Source Endowment – new funding source for open source maintainers
- Open Source Security at Astral
- Open source calculator firmware DB48X forbids CA/CO use due to age verification
- OpenAI Backs Bill That Would Limit Liability for AI-Enabled Mass Deaths
- OpenAI Fires an Employee for Prediction Market Insider Trading
- OpenAI agrees with Dept. of War to deploy models in their classified network
- OpenAI closes funding round at an $852B valuation
- OpenAI fires an employee for prediction market insider trading
- OpenAI is walking away from expanding its Stargate data center with Oracle
- OpenAI reaches deal to deploy AI models on U.S. DoW classified network
- OpenAI resets spending expectations, from $1.4T to $600B
- OpenAI – How to delete your account
- OpenAI's $110B funding round (investments from Amazon, Nvidia, SoftBank)
- OpenAI's fall from grace as investors race to Anthropic
- OpenAI, the US government and Persona built an identity surveillance machine
- OpenBSD on SGI: A Rollercoaster Story